Now Offering Prolozone Therapy

Prolozone Therapy

What is Prolozone Therapy?

Prolozone Therapy is a form of non-surgical ligament and joint reconstruction pioneered by Frank Shallenberger, MD. It is a permanent treatment for many kinds of chronic pain. Prolozone Therapy is derived from the Latin word “prolix” which means to proliferate, regenerate, and rebuild. Prolozone Therapy is so named because the treatment uses ozone to cause the proliferation, regeneration, and rebuilding of new ligament and cartilage tissue in areas where they have become weak.

Injured Ligaments Cause Pain

Ligaments are the structural “rubber bands” that hold the bones, joints and intervertebral discs together. Ligaments can become weak or injured from injury excessive use, or surgery, and often do not heal back to their original strength and tightness. When this happens, this puts a severe strain on the areas that the ligaments are supposed to be holding together, resulting in pain and arthritis in the bones, discs, and joints which are affected. Also, ligaments themselves have many nerve endings which can provide additional source of pain.

How Does it Work?

Prolozone Therapy involves the injection of ozone in and around ligaments where they attach to the bone. The injected ozone increases the blood supply and flow of healing nutrients. More importantly, it also stimulates the deposition and activity of fibroblasts and chondroblasts. These cells synthesize the collagen and cartilage that the body uses to repair damaged ligaments and joints. This increase in cellular repair activity strengthens and tightens the injured tissues; thereby stabilizing the area, and removing the cause of the pain.

Why is Ozone Used?

Ozone is a naturally-occurring highly reactive molecule consisting of three atoms of oxygen. Because ozone is so reactive, it is able to stimulate fibroblastic and chondroblastic activity to an almost unbelievable extent. This high level of reactivity, combined with the innate safety of oxygen, makes ozone the ideal therapeutic molecule.

What Can I Expect?

The response to treatment varies from individual to individual, and depends upon one’s healing ability and level of injury. Some people may only need one to two treatments, while others may need as many as six or seven. Once you being treatment, the doctor can analyze how you are responding, and will then be able to give you an accurate estimate of what you can expect from further treatments. The inject process is repeated every 1-2 weeks until maximum improvement is noted. Prolozone Therapy typically results in a complete absence of symptoms, even in severe pain conditions that have been present for years. And, the most amazing thing about it is that the results usually represent a permanent fix.

What Conditions are Treated?

Back and neck pain with or without degenerative disk disease, shoulder pain from rotator cuff injuries, and osteoarthritis of the hips, knees and spine are the most common ailments treated with Prolozone Therapy. Prolozone Therapy is also excellent for many other types of musculo-skeletal pain, including fibromyalgia, carpal tunnel syndrome, TMJ syndrome, sciatica, plantar fascititis, neuromas, tennis elbow and virtually any sports injuries. It can be especially effective in treating areas that have previously been operated on because of the significant injury that occurs to ligaments during surgery.


Prolozone Therapy is a safe, natural and often permanent treatment for low back pain, degenerated or herniated discs, sciatica, neck pain, unresolved whiplash, rotator cuff tears and osteo-arthritis of the hip or knee.

Prolotherapy is a minimally-invasive injectional technique that assists with cartilage regrowth and the strengthening of ligaments and tendons in the ankle, back, neck, knee, arm, foot, and hip. By strengthening these joint structures, clients can often suspend invasive surgeries such as hip, knee replacements or ankle surgeries or assist with recovery post-op. Typical prolotherapy solution consists of sterile dextrose with a local anesthetic along with vitamin B12. Prolozone is simply the additional use of ozone gas into affected muscle or bony area in place of the dextrose solution; prolozone has the added benefit of stimulating stem cell growth. Prolozone has been used on racehorses and Olympic athletes.

Prolotherapy/ Regenerative Injection Therapy

1 – RIT/PROLOTHERAPY AND PROLOZONE are methods of treatment that provides Long-term relief from pain.

2 – Stimulates your body’s own natural healing ability.

3 – Significantly improves functions of daily living and restores your quality of life

The new Prolotherapy by Dr. Robert Jay Rowen. (March 2009)

Prolotherapy has gone to a new and better level of pain relief and joint repair. This is a modification of Prolotherapy that provides outstanding proven results based on case studies. The new technique was developed by Dr. Frank Shallenberger and is called:


This procedure uses an oxygen/ozone gas mixture which directs oxidation to the affected painful area. The affected area is anesthetized with procaine, a local anesthetic, vitamin B12 and folic acid is added to the procaine. This combination stimulates the DNA of cells to start repairs to the damaged joint and relieves pain at once. Oxygen/ozone is the most critical nutrient for energy production and healing and is the magic ingredient in the new prolotherapy.

Dr. Robert Jay Rowan said the meniscus doesn’t repair itself because cartilage does not have a blood supply. It receives is oxygen and nutrients from the synovial fluid that baths the joints. Nutrition must migrate in through osmosis. Very good results have been obtained by injection ozone directly into the joint. Ozone is a very active form of oxygen and it stimulates cartilage growth and can stimulate damaged articular cartilage back to reasonable function. The meniscus is a piece of cartilage between the femur and tibia, not on the bone surface. Another approach is growth hormone which also stimulates cartilage growth. Combine Ozone, growth hormone and prolotherapy for joint problems have had wonderful results according to my colleagues.

“According to reports I have received, prolotherapy/ PROLOZONE®. has helped joint mechanics almost no matter the underlying problem“.

The ligaments and tendons produced after RIT/Prolotherapy appear much the same as normal tissue, except that they are thicker, stronger, and contain fibers of varying thickness, testifying to the new and on going creation of tissue which stimulates the natural healing process. The injections stimulate blood vessel growth into tissues. This increases oxygen, nutrients and growth factor delivery to the areas in the joint structure which facilitates healing.

In a double blind human study, in which neither the patients nor the researchers knew who were receiving the treatment, 88.5% of those injected with the reconstructive solution (RIT/Prolotherapy) showed improvement and the other study group showed 0% improvement. It is a very conservative treatment and doesn’t remove or replace parts or weakened areas of the body. There are no side effects such as possible blood clots or infection that sometimes occur with joint replacements. There is no downtime, usually the injections are done in the late afternoon and you can return to work or play the next day.

The PROLOZONE® injection consist of the following medications

Oxygen/ozone gas mixture instead of the prolo solution. The affected joint is anesthetized with procaine which is a local anesthetic.

B12 and folic acid is added to the procaine and this combination will stimulate the DNA of cells to jump into repair action faster and longer than other treatments.

Oxygen called ozone is the most critical nutrient for energy production and healing. It stimulates the cells to excrete waste material and promotes their ability to repair themselves and the tissues around them. This makes PROLOZONE® a miracle healer as ozone is a powerful stimulant of cellular growth factors such as Transforming Growth Factor Beta (TGF-B).

The full report can be found in Dr. Robert Jay Rowen’s Second Opinion Newsletter March 2009 Vol. XIX NO 3.

Dr. Frank Shallenberger’s website

List Of painful conditions that have been successfully treated with rit/prolozone therapy

  • Chronic pain from sports, vehicle, home or work-related injuries
  • Neck, including (whip-lash), upper and lower Back, sacroiliac joint pain
  • Shoulder (rotator cuff injury), tennis /golfer’s elbow, wrist, hand, osteoarthritis, pain or tendinosus
  • Hip, groin sprain, knee, foot or ankle pain
  • Complex Regional Pain Syndrome (CRPS, RSD)
  • Degenerative Disc Disease in the neck, upper and lower back
  • Cervicogenic headaches (coming from the neck)
  • Myofascial pain syndromes
  • Pain Persistent After Spine Surgery
  • Piriformis Syndrome
  • Sciatica and TMJ
  • Spondylosis (Spinal Arthritis)

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